This brief is an in-depth analysis of how Title I, Part A, of the Elementary and Secondary Education Act and the McKinney-Vento Homeless Assistance Act work together to support children and youth experiencing homelessness. It outlines statutory requirements for cross-program collaboration, such as appointing state coordinators and local liaisons, and describes methods for optimizing resource allocation and service provision. The brief highlights strategies for assessing student needs, determining homeless set-aside funding, and implementing targeted interventions like tutoring, counseling, and access to school supplies. Practical recommendations are provided for state and district leaders to foster ongoing communication, joint planning, and data sharing that enhance the educational outcomes of homeless students.